| Page 44 | Kisaco Research

Key Takeaways: 

  • We have developed technology that efficiently applies predictive ML models to combinatorial synthesis libraries (CSLs) at a rate of ~500 B compounds per second, per GPU, allowing us to exhaustively evaluate otherwise enumerable chemical space to identify diverse compounds that best fit multi-parameter optimization criteria.
  • In practice, this gives chemists the opportunity to flexibly and iteratively explore enormous chemical space while receiving results, in the form of enumerated chemical structures, within seconds of their inquiry, fostering a genuine creative process that leads to higher chemical diversity and developability.
  • We use this approach in conjunction with our next-generation extrapolative ML models, which has allowed us to discover high-quality, diverse, structurally-distinct binders for targets of interest; however, this approach can be extended to any advanced predictive model in order to exhaustively evaluate any CSL.

Author:

Rameez Chatni

Global Director, AI Solutions, Pharmaceutical & Life Sciences
Cloudera

Rameez Chatni

Global Director, AI Solutions, Pharmaceutical & Life Sciences
Cloudera

Author:

Frédéric Chabot

Head of Corporate Development
MindWalk

Frédéric Chabot is the Head of Corporate Development at MindWalk, focusing on M&A, strategic partnerships, and corporate initiatives. He began working with IPA in 2017, contributing in various roles before assuming his current position. With over 26 years of experience in finance and corporate strategy, he navigates biotech investments and market expansion.

Previously, he served as an International Liaison at Contact Financial, an advisory firm specializing in capital raising and investor relations for TSX and TSX-V listed companies. Over nine years, he worked on investor awareness programs and fundraising initiatives, supporting startups and early-stage companies.

Frédéric Chabot

Head of Corporate Development
MindWalk

Frédéric Chabot is the Head of Corporate Development at MindWalk, focusing on M&A, strategic partnerships, and corporate initiatives. He began working with IPA in 2017, contributing in various roles before assuming his current position. With over 26 years of experience in finance and corporate strategy, he navigates biotech investments and market expansion.

Previously, he served as an International Liaison at Contact Financial, an advisory firm specializing in capital raising and investor relations for TSX and TSX-V listed companies. Over nine years, he worked on investor awareness programs and fundraising initiatives, supporting startups and early-stage companies.

Author:

Justin Byers

Founder and Chief Executive Officer
Axio BioPharma

Justin Byers is the Founder and Chief Executive Officer of Axio BioPharma, an AI biomanufacturing company revolutionizing how monoclonal antibodies are developed and produced. Based in Madison, Wisconsin, Axio launched in 2024 with a mission to accelerate and de-risk the development of recombinant proteins and monoclonal antibodies through AI-driven process design and U.S.-based manufacturing.

Under Justin’s leadership, Axio has pioneered a data-rich, machine learning–powered approach that reduces process development timelines from years to days unlocking faster, more cost-efficient pathways for biotech partners. He has steered the company’s rapid growth, from establishing its state-of-the-art facilities to securing strategic partnerships, including collaborations to advance next-generation drug delivery technologies.

With a background at the intersection of biomanufacturing, technology, and entrepreneurship, Justin brings a vision of scaling biologics development with speed, reliability, and accessibility. He is committed to building Axio into a trusted partner for innovators worldwide, combining scientific rigor with cutting-edge AI to bring life-changing therapies to patients faster.

Justin Byers

Founder and Chief Executive Officer
Axio BioPharma

Justin Byers is the Founder and Chief Executive Officer of Axio BioPharma, an AI biomanufacturing company revolutionizing how monoclonal antibodies are developed and produced. Based in Madison, Wisconsin, Axio launched in 2024 with a mission to accelerate and de-risk the development of recombinant proteins and monoclonal antibodies through AI-driven process design and U.S.-based manufacturing.

Under Justin’s leadership, Axio has pioneered a data-rich, machine learning–powered approach that reduces process development timelines from years to days unlocking faster, more cost-efficient pathways for biotech partners. He has steered the company’s rapid growth, from establishing its state-of-the-art facilities to securing strategic partnerships, including collaborations to advance next-generation drug delivery technologies.

With a background at the intersection of biomanufacturing, technology, and entrepreneurship, Justin brings a vision of scaling biologics development with speed, reliability, and accessibility. He is committed to building Axio into a trusted partner for innovators worldwide, combining scientific rigor with cutting-edge AI to bring life-changing therapies to patients faster.